Protein Details: Store-operated calcium entry-associated regulatory factor

Protein ID

ICDB_Pro_1296

Protein Name

Store-operated calcium entry-associated regulatory factor

Gene Name

Saraf; Tmem66

Organism

Mus musculus (Mouse)

Length

334 amino acids

AlphaFoldDB

AF-Q8R3Q0-F1-model_v4.pdb

Function

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling; promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels; and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity).

Sequence

MAVAAVGRPRALRCPLLLLLSLLLVAGPALGWNDPDRILLRDVKALTLYSDRYTTSRRLDPIPQLKCVGGTAGCEAYTPRVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKLKESGKHQGFSDYYHKLYSSDSCGFITIAVLFVLAFAVYKLFLSDGQGSPPPYSEHPPYSEHSQRFASAAGAPPPGFKSEFTGPQNTGYGASSGFGSAFGGQGYGSSGPGFWSGLGAGGLLGYLFGSNRAATPFSDSWYHPAYPPSHSGAWNSRAYSPLGGGAGSYCASSNADSRTRTASGYGGTRRR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001

RefSeq

NP_080708.3